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My sister has arthritis and lupus. How genetic is that? Could I have them too? |
My sister has arthritis and lupus. How genetic is that? Could I have them too? Many researchers think that lupus is hereditary, meaning it is passed on genetically from one generation to another. The pattern of inheritance is, however, unclear. It is known that not everyone who has the lupus genes develops the disease, as demonstrated in numerous identical twin studies (concordance, or the rate at which both identical twins are affected with lupus, varies from 15-69%). This information indicates, first, that people who have lupus genes have a genetic predisposition to the disease, or a higher likelihood of developing it, than the general population. Merely having lupus-linked genes is not enough to cause a person to develop lupus. This in turn indicates that an external or environmental trigger is also involved in lupus disease onset in people with the genetic predisposition. (Known triggers include stress, hormonal changes, illness, certain viruses including Epstein-Barr virus and chemical exposure). Ten percent of lupus patients have a first-degree relative (sister, daughter, son, mother) or a second-degree relative (aunt, uncle, first cousin) with lupus. Therefore, 90 percent of lupus patients DO NOT have relatives with lupus. Even in identical twins, when one sibling has lupus and the other twin does not, it is believed there are environmental factors that play an important role. Heredity And Overlap * It is unusual (less than 10 percent of the time) for a person with lupus to have a close family member (parent, child, brother, or sister) who also suffers from lupus. * However, it is common for persons with lupus to have relatives (including grandparents, aunts/uncles, cousins) with other connective tissue diseases such as rheumatoid arthritis, Sjogren's syndrome, scleroderma, etc. * These co-occurrences raise the possibility that heredity may be a factor in all of the connective tissue diseases. * Most scientists agree that important hereditary associations with these diseases are present in some families. Additional research is needed to shed light on this important question. Source(s): http://www.lupusny.org/faq.php http://72.14.209.104/search?q=cache:qnbd... http://www.lupus.org/education/brochures... I know arthritis is but sorry don't know about lupus |
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