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| *Women health>>>Lupus |
What is the new in lupus treatment? |
What is the new in lupus treatment? Lupus is an autoimmune disease: The body is attacked by its own immune system. In lupus, that attack may come from a kind of immune cell called a B cell. As the body makes new B cells, a few of them go haywire and try to attack the body. Normally, the body quickly eliminates these cells. But in lupus, they somehow survive. A special hormone called B-cell-activating factor -- or BAFF -- helps these self-attacking B cells survive. And people with lupus and some other autoimmune diseases overproduce BAFF. Eventually, these B cells build up to dangerous levels and cause lupus. Hiding in the Spleen Now a research team, including Michael Karin, PhD, of the University of California, San Diego, finds that B cells build up in a specific part of the spleen called the marginal zone. Mouse studies suggest that if the B cells can't hide in the spleen, they can't cause lupus. What lets lupus-causing B cells lurk in the spleen is a chain of chemical signals called the NF-kB pathway. You need a functional NF-kB pathway for your immune system to fight infections. But this pathway is made up of two parts: the classical NF-kB pathway and the alternative NF-kB pathway. In mouse experiments, Karin's team now finds that partial disruption of just the alternative NF-kB pathway is enough to keep lupus-causing B cells from hiding in the spleen. "Our findings suggest that incomplete inhibition of the alternative NF-kB pathway 鈥?may be a sufficient therapeutic option for patients suffering from autoimmune disease associated with BAFF overproduction," the researchers suggest. "Inhibition of the alternative NF-kB pathway is less likely to cause an immune deficiency, which is commonly seen after blockade of the classical NF-kB pathway." |
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Lupus is an autoimmune disease: The body is attacked by its own immune system. In lupus, that attack may come from a kind of immune cell called a B cell. As the body makes new B cells, a ... Greetings!! A fantastic website for those with Lupus and/or any other autoimmune (AI) disease is the virtual village at: ... I have (SLE) Lupus. Anti Coagulate is a blood test to determine if your blood clots or not. If you have clotting issues with your blood, the doctor may want to put you on Coumadin (a blood ... yes, it is possible, put not neccessarily definitive. It depends on if he inherited the gene for lupus...... Did you ask your doctor? They've usually got the resources for stuff like that. Sorry to hear the bad news. Take care...... Lupu is an autoimmune disease. Like all autoimmune diseases they react differently in different individuals with different symptoms. An autoimmune disorder means that the bodies natural immu... www.lupus.org... I have an auto immune disease and i had no insurance..if u r sick..go to the Dr ..then once they diagnose u,they can help you to get medical assistance.good luck...(thats what i did)... |
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