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Drug for multiple sclerosis?


Do you know abuot a new drug for multiple sclerosis named IVIG? Do you know what is its active ingredient?
Thanks!

Few clinical trials have studied intravenous immune globulin (IVIG) in progressive forms of MS, and these have shown little or no benefit .

A double-blind, placebo-controlled study of 67 patients with an apparently irreversible motor deficit found that IVIG (0.4 g/kg for five days, then single infusions every two weeks for three months) did not reverse established weakness in MS .
A larger trial randomly assigned 318 patients with clinically definite secondary progressive MS to monthly IVIG or placebo for 27 months . There was no difference between the IVIG and placebo groups on any of the clinical outcome measures or in change in T2 lesion load on MRI scan over time.
Based primarily on the latter study, treatment with IVIG for progressive MS cannot be recommended. IVIG has shown possible benefit for relapsing MS in clinical trials. it appears that IVIG reduces the attack rate in relapsing MS and that IVIG is of little benefit for slowing disease progression

There have been two clinical trials for IVIG (Intravenous Immune Globulin)and MS.

A Phase III trial began at the Mayo Clinic in 1993. Study patients had relapsing-remitting or relapsing-progressive MS. The study is ongoing, but not recruiting participants. Findings have not been released yet.

A Phase II trial was completed at Mt Sinai Medical Center in 2002-2005. Study patients had relapsing-remitting MS. The study is ongoing, but not recruiting participants. The study found the difference in relapse rate between the placebo and IGIV-C groups was not statistically significant.

(Phase II clinical trials determine if the study drug is effective and to further evaluate its safety. Phase III clinical trials confirm the study drug's effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.)

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